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CAS No.: 130-86-9

原阿片碱 Catalog No. CSN19448

Synonyms: Corydinine;Biflorine;Fumarine

Protopine is a naturally occuring benzylisoquinoline alkaloid found in plants of the family papaveraceae. It acts as an analgesic and can inhibit histamine H1 receptors.

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生物活性

描述Protopine is an isoquinoline alkaloid contained in plants in northeast Asia. Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E(2) (PGE(2)) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines^[3]. Protopine markedly improved the renal function, relieve inflammation, reversed inflammatory cytokines, transformed apoptosis markers, and regulated the TLR4 (Toll-like receptor) signaling pathway in mice with AKI (acute kidney injury) induced by LPS (lipopolysaccharide)^[4]. Protopine increased the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as Bcl-2 phosphorylation and Mcl-1 down-regulation^[5]. In HepG2 cells, protopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations at 25 and 10 μM. Protopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8299 mL
- 14.1495 mL
- 28.2991 mL
- 5 mM
- 0.5660 mL
- 2.8299 mL
- 5.6598 mL
- 10 mM
- 0.2830 mL
- 1.4150 mL
- 2.8299 mL

技术信息

CAS号

130-86-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H19NO5

运输

蓝冰

分子量

353.37

别名

Corydinine;Biflorine;Fumarine;原阿片碱

溶解度

DMSO	40.0 mg/mL (113.2 mM)
Water	insoluble

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